Chemogenomics: Methods And Applications (Methods In Molecular Biology (575), Band 575)
Autor : Edgar Jacoby
Geschlecht : Bücher, Fachbücher, Medizin & Gesundheitsdienste,
lesen : 6708
Herunterladen : 5590
Dateigröße : 37.15 MB
Format : PDF, ePub
Pressestimmen From the reviews: “Provide practical and authoritative reviews on current research topics. … The present book represents an illustrative compendium of up-to-date chemogenomics, with a strong emphasis on bio- and cheminformatic concepts. … It therefore represents a valuable complement to published books that are more ‘chemical biology’ driven. It is of particular interest for the ‘data miners’ of the chemogenomics community, giving them an authoritative overview of current technologies and methods available throughout industry and academia.” (Markus Kaiser, ChemBioChem, Vol. 11, March, 2010) Buchrückseite The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology™ series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.